iuvo Guardian focuses on managing and optimizing the security and configuration aspects of Microsoft 365 for your business without manual oversight. Simply put, it makes sure your Microsoft 365 setup is configured correctly and securely according to the latest best practices without manual effort from you or your employees. This could include things like adjusting the settings for compliance with data protection regulations, making sure that your security configurations are up to date, and optimizing your settings for better performance and security.
Microsoft Defender on the other hand is geared more towards direct threat protection and response within your Microsoft ecosystem. Microsoft Defender detects, investigates and responds to security threats like Malware, viruses and Spyware.